Differential Mass Spectrometry of Rat Plasma Reveals Proteins That Are Responsive to 17β-Estradiol and a Selective Estrogen Receptor Modulator PPT
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- 作者：Xuemei Zhao ; Ekaterina G. Deyanova ; Laura S. Lubbers ; Pete Zafian ; Jenny J. Li ; Andy Liaw ; Qinghua Song ; Yi Du ; Robert E. Settlage ; Gerry J. Hickey ; Nathan A. Yates ; Ronald C. Hendrickson
- 刊名：Journal of Proteome Research
- 出版年：2008
- 出版时间：October 3, 2008
- 年：2008
- 卷：7
- 期：10
- 页码：4373-4383
- 全文大小：429K
- 年卷期：v.7,no.10(October 3, 2008)
- ISSN：1535-3907
文摘
Estrogens are a class of steroid hormones that interact with two related but distinct nuclear receptors, estrogen receptor (ER) α and β. To identify potential ER biomarkers, we profiled the rat plasma glycoproteome after treatment with vehicle or 17β-estradiol (E2) or an ERα-selective agonist PPT by differential mass spectrometry. Our comparative proteomic experiment identifies novel E2- and PPT-responsive proteins, such as serine protease inhibitor family members.