Production of Lantipeptides in Escherichia coli
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- 作者：Yanxiang Shi ; Xiao Yang ; Neha Garg ; Wilfred A. van der Donk
- 刊名：Journal of the American Chemical Society
- 出版年：2011
- 出版时间：March 2, 2011
- 年：2011
- 卷：133
- 期：8
- 页码：2338-2341
- 全文大小：803K
- 年卷期：v.133,no.8(March 2, 2011)
- ISSN：1520-5126
文摘
Lantipeptides are ribosomally synthesized and posttranslationally modified peptides containing thioether cross-links. We describe the preparation of seven different lantipeptides in Escherichia coli and demonstrate that this methodology can be used to incorporate nonproteinogenic amino acids.