Total Synthesis of Thailanstatin A

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• 作者：K. C. Nicolaou ; Derek Rhoades ; Manjunath Lamani ; Manas R. Pattanayak ; S. Mothish Kumar
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：June 22, 2016
• 年：2016
• 卷：138
• 期：24
• 页码：7532-7535
• 全文大小：382K
• 年卷期：0
• ISSN：1520-5126

文摘

The total synthesis of the spliceosome inhibitor thailanstatin A has been achieved in a longest linear sequence of nine steps from readily available starting materials. A key feature of the developed synthetic strategy is the implementation of a unique, biomimetic asymmetric intramolecular oxa-Michael reaction/hydrogenation sequence that allows diastereodivergent access to highly functionalized tetrahydropyrans, which can be used for the synthesis of designed analogues of this bioactive molecule.