Synthesis and Antiviral Activity Evaluation of Nitroporphyrins and Nitrocorroles as Potential Agents against Human Cytomegalovirus Infection

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• 作者：Claude P. Gros ; Nicolas Desbois ; Clément Michelin ; Eloise Demilly ; Anne-Françoise Tilkin-Mariamé ; Bernard Mariamé ; Franck Gallardo
• 刊名：ACS Infectious Diseases
• 出版年：2015
• 出版时间：August 14, 2015
• 年：2015
• 卷：1
• 期：8
• 页码：350-356
• 全文大小：453K
• ISSN：2373-8227

文摘

Different nitroporphyrinoid derivatives were synthesized and studied as potential agents against human Cytomegalovirus. Interestingly, two nitrocorroles display strong activity against human Cytomegalovirus with IC₅₀ < 0.5 μM. These compounds also possess antiproliferative activities without detected in vivo toxicity. Therefore, nitrocorroles appear for the first time as potential active compounds that can be applied in human health.