Cucurbitane-Type Triterpenoids from the Fruits of Momordica charantia and Their Cancer Chemopreventive Effects

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• 作者：Toshihiro Akihisa ; Naoki Higo ; Harukuni Tokuda ; Motohiko Ukiya ; Hiroyuki Akazawa ; Yuichi Tochigi ; Yumiko Kimura ; Takashi Suzuki ; Hoyoku Nishino
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：August 2007
• 年：2007
• 卷：70
• 期：8
• 页码：1233 - 1239
• 全文大小：101K
• 年卷期：v.70,no.8(August 2007)
• ISSN：1520-6025

文摘

Thirteen cucurbitane-type triterpene glycosides, including eight new compounds named charantosides I (6), II (7), III(10), IV (11), V (12), VI (13), VII (16), and VIII (17), and five known compounds, 8, 9, 14, 15, and 18, were isolatedfrom a methanol extract of the fruits of Japanese Momordica charantia. The structures of the new compounds weredetermined on the basis of spectroscopic methods. On evaluation of these triterpene glycosides and five other cucurbitane-type triterpenes, 1-5, also isolated from the extract of M. charantia fruits, for their inhibitory effects on the inductionof Epstein-Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, thesecompounds showed inhibitory effects on EBV-EA induction with IC₅₀ values of 200-409 mol ratio/32 pmol TPA. Inaddition, upon evaluation of compounds 1-5 for inhibitory effects against activation of (±)-(E)-methyl-2[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitrogen oxide (NO) donor, compounds 1-3 showed moderateinhibitory effects. Compounds 1 and 2 exhibited marked inhibitory effects in both 7,12-dimethylbenz[a]anthracene(DMBA)- and peroxynitrite (ONOO^-; PN)-induced mouse skin carcinogenesis tests.