Azaphilones, Furanoisophthalides, and Amino Acids from the Extracts of Monascus pilosus-Fermented Rice (Red-Mold Rice) and Their Chemopreventive Effects

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• 作者：Toshihiro Akihisa ; Harukuni Tokuda ; Ken Yasukawa ; Motohiko Ukiya ; Ayaka Kiyota ; Naoyuki Sakamoto ; Takashi Suzuki ; Nobukazu Tanabe ; and Hoyoku Nishino
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2005
• 出版时间：February 9, 2005
• 年：2005
• 卷：53
• 期：3
• 页码：562 - 565
• 全文大小：57K
• 年卷期：v.53,no.3(February 9, 2005)
• ISSN：1520-5118

文摘

Six azaphilones, monascin (1), ankaflavin (2), rubropunctatin (3), monascorburin (4), rubropunctamine(5), and monascorburamine (6), two furanoisophthalides, xanthomonasin A (7) and xanthomonasinB (8), and two amino acids, (+)-monascumic acid (9) and (-)-monascumic acid (10), isolated fromthe extracts of Monascus pilosus-fermented rice (red-mold rice) were evaluated for their inhibitoryeffects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, on the inductionof Epstein-Barr virus early antigen (EBV-EA) by TPA in Raji cells, and on the activation of (±)-(E)-methyl-2[(E)-hydroxy-imino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor. Amongthe compounds tested, seven compounds (1-6 and 10) on TPA-induced inflammation, and sixcompounds (1, 3-5, 9, and 10) on EBV-EA activation, exhibited potent inhibitory effects. All of thecompounds tested showed moderate inhibitory effects on NOR 1 activation.Keywords: Monascus pilosus; red-mold rice; azaphilones; furanoisophthalides; amino acids; TPA-induced ear edema; antitumor-promoter; Epstein-Barr virus early antigen