Concentrations of Bisphenol A and Seven Other Phenols in Pooled Sera from 3鈥?1 Year Old Children: 2001鈥?002 National Health and Nutrition Examination Survey

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• 作者：Xiaoyun Ye ; Xiaoliu Zhou ; Lee-Yang Wong ; Antonia M. Calafat
• 刊名：Environmental Science & Technology (ES&T)
• 出版年：2012
• 出版时间：November 20, 2012
• 年：2012
• 卷：46
• 期：22
• 页码：12664-12671
• 全文大小：231K
• 年卷期：v.46,no.22(November 20, 2012)
• ISSN：1520-5851

文摘

Concerns exist regarding children鈥檚 exposure to bisphenol A (BPA) and other phenols because of the higher sensitivity, compared to adults, of children鈥檚 developing organs to endocrine disruptors. Several studies reported the urinary concentrations of these phenols in children, but data on levels of these compounds in children鈥檚 serum are limited. We present here the total (free plus conjugated) and free concentrations of BPA and seven other phenols in 24 pooled serum samples prepared from individual specimens collected from 936 children 3鈥?1 years old who participated in the 2001鈥?002 National Health and Nutrition Examination Survey. We detected benzophenone-3, triclosan, 2,4-dichlorophenol, 2,5- dichlorophenol, and three parabens in at least 60% of the pools suggesting children鈥檚 exposure to these compounds or their precursors. Conjugated phenols were the major species. However, although many previous studies have shown widespread detection of BPA in children鈥檚 urine, we only detected total or free BPA in 3 and 2 pooled serum samples, respectively, at concentrations of 0.1鈥?.2 渭g/L. The nonpersistent nature of BPA and the phenols examined and the likely episodic nature of the exposures to these compounds (or their precursors) suggest that for general population biomonitoring of these nonpersistent phenols, urine, not serum or plasma, is the preferred matrix.