Fluorescein Analogue Xanthene-9-Carboxylic Acid: A Transition-Metal-Free CO Releasing Molecule Activated by Green Light
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- 作者：Lovely Angel Panamparambil Antony ; Tom谩拧 Slanina ; Peter 艩ebej ; Tom谩拧 艩olomek ; Petr Kl谩n
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：September 6, 2013
- 年：2013
- 卷：15
- 期：17
- 页码：4552-4555
- 全文大小：240K
- 年卷期：v.15,no.17(September 6, 2013)
- ISSN：1523-7052
文摘
6-Hydroxy-3-oxo-3H-xanthene-9-carboxylic acid is introduced as the first transition-metal-free carbon monoxide releasing molecule activated by visible light (photoCORM). This water-soluble fluorescein analogue releases carbon monoxide in both water and methanol upon irradiation at 500 nm. When selectively irradiated in the presence of hemoglobin (Hb) under physiological conditions, released CO is quantitatively trapped to form carboxyhemoglobin (COHb). The reaction progress can be accurately monitored by characteristic absorption and emission properties of the reactants and products.