Structure and Semisynthesis of Platensimide A, Produced by Streptomyces platensis
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- 作者：Kithsiri B. Herath ; Chaowei Zhang ; Hiranthi Jayasuriya ; John G. Ondeyka ; Deborah L. Zink ; Bruce Burgess ; Jun Wang ; Sheo B. Singh
- 刊名：Organic Letters
- 出版年：2008
- 出版时间：May 1, 2008
- 年：2008
- 卷：10
- 期：9
- 页码：1699 - 1702
- 全文大小：102K
- 年卷期：v.10,no.9(May 1, 2008)
- ISSN：1523-7052
文摘
Platensimycin and platencin are novel natural product antibiotics that inhibit bacterial growth by inhibiting condensing enzymes FabF and FabF/FabH of fatty acid biosynthesis pathways, respectively. Continued search for the natural congeners of these compounds led to the isolation of platensic acid, the free C-17 tetracyclic enoic acid, and platensimide A, a 2,4-diaminobutyric acid amide derivative. Isolation, structure, semisynthesis, and activity of these compounds are described.