Copper-Catalyzed Radical [2 + 2 + 1] Annulation of Benzene-Linked 1,n-Enynes with Azide: Fused Pyrroline Compounds

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• 作者：Xuan-Hui Ouyang ; Ren-Jie Song ; Yu Liu ; Ming Hu ; Jin-Heng Li
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：December 18, 2015
• 年：2015
• 卷：17
• 期：24
• 页码：6038-6041
• 全文大小：422K
• ISSN：1523-7052

文摘

A novel selective copper-catalyzed radical [2 + 2 + 1] annulation of benzene-linked 1,n-enynes with azido-benziodoxolone to access fused pyrroline compounds, including 3H-pyrrolo[3,4-c]quinolin-4(3aH)-ones, chromeno[3,4-c]pyrrol-4(9bH)-one, and indeno[1,2-c]pyrroline, has been developed, which proceeds via the addition of the azide radical to the alkene, annualtion, and azidation cascade.