The CH鈭捪€ Interactions of Methyl Ethers as a Model for Carbohydrate鈥?i>N-Heteroarene Interactions
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- 作者：Ping Li ; Trent M. Parker ; Jungwun Hwang ; Fengyuan Deng ; Mark D. Smith ; Perry J. Pellechia ; C. David Sherrill ; Ken D. Shimizu
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：October 3, 2014
- 年：2014
- 卷：16
- 期：19
- 页码：5064-5067
- 全文大小：342K
- ISSN：1523-7052
文摘
CH鈭捪€ interactions have been cited as an important contributor to carbohydrate recognition. To determine whether N-heterocycles form stronger CH鈭捪€ interactions, the interactions of methyl ether groups with heterocyclic and nonheterocyclic aromatic surfaces were studied. Both experimental and computational experiments found that N-heterocyclic aromatic surfaces formed stronger interactions. This enhancement was attributed to attractive dipole鈥揹ipole interactions between the methyl ether C鈥揙 bond and the N-heterocyclic aromatic dipole.