Ultrasound-Triggered BSA/SPION Hybrid Nanoclusters for Liver-Specific Magnetic Resonance Imaging

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• 作者：Bingbo Zhang ; Qi Li ; Peihao Yin ; Yuanpeng Rui ; Yanyan Qiu ; Yan Wang ; Donglu Shi
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2012
• 出版时间：December 26, 2012
• 年：2012
• 卷：4
• 期：12
• 页码：6479-6486
• 全文大小：494K
• 年卷期：v.4,no.12(December 26, 2012)
• ISSN：1944-8252

文摘

Nanoclusters of superparamagnetic iron oxide nanoparticles (SPION) are developed for liver-specific magnetic resonance imaging (MRI) by a unique synthesis route. The process is efficient, environmentally benign, and straight forward within five minutes. The clustering effect is triggered in the presence of bovine serum albumin (BSA) aqueous phase under ultrasonication condition. The hydrophobic SPION are densely self-assembled into BSA/SPION hybrid nanoclusters with a uniform size of 86 nm. The as-prepared BSA/SPION hybrid nanoclusters are found to be biocompatible and stable. They exhibit high transverse relaxivity and longitudinal relaxivity in water (r₂ and r₁ values are 600.8 and 4.3 s^鈥? per mM of Fe³⁺, respectively). In vivo T₂-weighted MRI shows excellent enhancement in liver with an imaging time-window up to 48 h. In vivo biodistribution study indicates a gradual excretion of the nanoclusters via hepatobiliary (HB) processing. No toxicity is observed in the in vivo and ex vivo experiments. The BSA/SPION hybrid nanoclusters present great potential in MRI as the liver-specific contrast agents (CAs).

Keywords:

iron oxide; bovine serum albumin; ultrasound; magnetic resonance imaging; liver