Copper-Catalyzed P-Arylation via Direct Coupling of Diaryliodonium Salts with Phosphorus Nucleophiles at Room Temperature

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• 作者：Jian Xu ; Pengbo Zhang ; Yuzhen Gao ; Yiyin Chen ; Guo Tang ; Yufen Zhao
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：August 16, 2013
• 年：2013
• 卷：78
• 期：16
• 页码：8176-8183
• 全文大小：418K
• 年卷期：v.78,no.16(August 16, 2013)
• ISSN：1520-6904

文摘

A new method for copper-catalyzed P鈥揅 bond formation through reaction of phosphorus nucleophiles with diaryliodonium salts at room temperature is described. Most target products are obtained with this method in high yields within a short reaction time of 10 min. It can be easily adapted to large-scale preparations. When unsymmetrical iodonium salts are employed, nucleophilic substitution occurs preferentially on the sterically hindered aromatic ring or the more electron-deficient ring.