Self-Complementary Quadruply Hydrogen-Bonded Duplexes Based on Imide and Urea Units

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• 作者：Xianghui Li ; Yuyu Fang ; Pengchi Deng ; Jinchuan Hu ; Tian Li ; Wen Feng ; Lihua Yuan
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：September 2, 2011
• 年：2011
• 卷：13
• 期：17
• 页码：4628-4631
• 全文大小：775K
• 年卷期：v.13,no.17(September 2, 2011)
• ISSN：1523-7052

文摘

The quadruply hydrogen-bonded duplexes based on an imide-urea structure preorganized by three-center hydrogen bonds were found to associate via bifurcated hydrogen bonds. ¹H NMR dilution experiments revealed the high stability of the homodimer in apolar solvent (K_dim > 10⁵ M^鈥? in CDCl₃) and enhancement of association ability due to electron-withdrawing substituent effects. The ready synthetic availability and adjustable association affinity via electronic effects may render these association units potentially applicable in constructing supramolecular architectures.