Triphase Interface Synthesis of Plasmonic Gold Bellflowers as Near-Infrared Light Mediated Acoustic and Thermal Theranostics

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• 作者：Peng Huang ; Pengfei Rong ; Jing Lin ; Wanwan Li ; Xuefeng Yan ; Molly Gu Zhang ; Liming Nie ; Gang Niu ; Jie Lu ; Wei Wang ; Xiaoyuan Chen
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：June 11, 2014
• 年：2014
• 卷：136
• 期：23
• 页码：8307-8313
• 全文大小：454K
• 年卷期：v.136,no.23(June 11, 2014)
• ISSN：1520-5126

文摘

We present a novel gold bellflower (GBF) platform with multiple-branched petals, prepared by a liquid鈥搇iquid鈥揼as triphase interface system, for photoacoustic imaging (PAI)-guided photothermal therapy (PTT). Upon near-infrared (NIR) laser irradiation, the GBFs, with strong NIR absorption, showed very strong PA response and an ultrahigh photothermal conversion efficiency (畏, 74%) among the reported photothermal conversion agents. The excellent performance in PAI and PTT is mainly attributed to the unique features of the GBFs: (i) multiple-branched petals with an enhanced local electromagnetic field, (ii) long narrow gaps between adjacent petals that induce a strong plasmonic coupling effect, and (iii) a bell-shaped nanostructure that can effectively amplify the acoustic signals during the acoustic propagation. Besides the notable PTT and an excellent PAI effect, the NIR-absorbing GBFs may also find applications in NIR light-triggered drug delivery, catalysis, surface enhanced Raman scattering, stealth, antireflection, IR sensors, telecommunications, and the like.