Deep-Red and Near-Infrared Xanthene Dyes for Rapid Live Cell Imaging

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• 作者：Guangle Niu ; Weimin Liu ; Bingjiang Zhou ; Hongyan Xiao ; Hongyan Zhang ; Jiasheng Wu ; Jiechao Ge ; Pengfei Wang
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：September 2, 2016
• 年：2016
• 卷：81
• 期：17
• 页码：7393-7399
• 全文大小：456K
• 年卷期：0
• ISSN：1520-6904

文摘

In this work, two xanthene dyes (H-hNR and TF-hNR) have been synthesized by a convenient and efficient method. These two dyes exhibited deep-red and near-infrared emissions, high fluorescence quantum yields, and good photostability. Their structure–optical properties were investigated by X-ray crystal structure analysis and density functional theory calculations. Live cell imaging data revealed that H-hNR and TF-hNR could rapidly stain both A549 and HeLa cells with low concentrations. The excellent photophysical and imaging properties render them as promising candidates for use in live cell imaging.