Synthesis and Characterization of Poly(vinylphosphonic acid-co-acrylic acid) Copolymers for Application in Bone Tissue Scaffolds
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- 作者：Rebecca E. Dey ; Xia Zhong ; Peter J. Youle ; Qi Guang Wang ; Ian Wimpenny ; Sandra Downes ; Judith A. Hoyland ; David C. Watts ; Julie E. Gough ; Peter M. Budd
- 刊名：Macromolecules
- 出版年：2016
- 出版时间：April 12, 2016
- 年：2016
- 卷：49
- 期：7
- 页码：2656-2662
- 全文大小：368K
- 年卷期：0
- ISSN：1520-5835
文摘
Poly(vinylphosphonic acid-co-acrylic acid) (PVPA-co-AA) has recently been identified as a possible candidate for use in bone tissue engineering. It is hypothesized that the strong binding of PVPA-co-AA to calcium in natural bone inhibits osteoclast activity. The free radical polymerization of acrylic acid (AA) with vinylphosphonic acid (VPA) has been investigated with varying experimental conditions. A range of copolymers were successfully produced and their compositions were determined quantitatively using 31P NMR spectroscopy. Monomer conversions were calculated using 1H NMR spectroscopy and a general decrease was found with increasing VPA content. Titration studies demonstrated an increase in the degree of dissociation as a function of VPA in the copolymer. However, a VPA content ca. 30 mol % was found to be the optimum for calcium chelation, suggesting that this composition is the most promising for biomaterials applications. Assessment of cell metabolic activity showed that PVPA-co-AA has no detrimental effect on cells, regardless of copolymer composition.