Grahamines A鈥揈, Cyclobutane-Centered Tropane Alkaloids from the Aerial Parts of Schizanthus grahamii

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• 作者：Sylvian Cretton ; Trixie A. Bartholomeusz ; Munir Humam ; Laurence Marcourt ; Yves Allenbach ; Damien Jeannerat ; Orlando Mu帽oz ; Philippe Christen
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：November 28, 2011
• 年：2011
• 卷：74
• 期：11
• 页码：2388-2394
• 全文大小：856K
• 年卷期：v.74,no.11(November 28, 2011)
• ISSN：1520-6025

文摘

Schizanthus grahamii is an endemic Chilean plant that is known to contain tropane alkaloids. Five new alkaloids, grahamines A鈥揈 (1鈥?b>5), were isolated and characterized by extensive spectroscopic analysis. Their structures were determined to be 2-{[(3伪-hydroxytropo-6尾-yl)oxy]carbonyl}-2-methyl-3-{[((6尾-angeloyloxy)-3伪-yl)oxy]carbonyl}-4-phenylcyclobutanecarboxylic acid (1), 2-{[(3伪-hydroxytropo-6尾-yl)oxy]carbonyl}-2-methyl-3-{[((6尾-tigloyloxy)-3伪-yl)oxy]carbonyl}-4-phenylcyclobutanecarboxylic acid (2), 1-methyl-2-{[(3伪-hydroxytropo-6尾-yl)oxy]carbonyl}-4-{[((6尾-angeloyloxy)-3伪-yl)oxy]carbonyl}-3-phenylcyclobutanecarboxylic acid (3), 1,2-bis{[(3伪-hydroxytropo-6尾-yl)oxy]carbonyl}-2-methyl-3-{[((6尾-angeloyloxy)-3伪-yl)oxy]carbonyl}-4-phenylcyclobutanecarboxylate (4), and 1-{[(3伪-mesaconyloxytropo-6尾-yl)oxy]carbonyl}-2-{[(3伪-hydroxytropo-6尾-yl)oxy]carbonyl}-2-methyl-3-{[((6尾-angeloyloxy)-3伪-yl)oxy]carbonyl}-4-phenylcyclobutanecarboxylate (5).