Concise Approach toward Tetrazolo[1,5-a][1,4]benzodiazepines via a Novel Multicomponent Isocyanide-Based Condensation

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• 作者：Roman S. Borisov ; Anatoliy I. Polyakov ; Lidia A. Medvedeva ; Victor N. Khrustalev ; Natalia I. Guranova ; Leonid G. Voskressensky
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：September 3, 2010
• 年：2010
• 卷：12
• 期：17
• 页码：3894-3897
• 全文大小：205K
• 年卷期：v.12,no.17(September 3, 2010)
• ISSN：1523-7052

文摘

A novel and efficient method for the synthesis of heteroannulated [1,4]benzodiazepines via an isocyanide-based multicomponent reaction is reported. The tetrazolo[1,5-a][1,4]benzodiazepines were obtained by a facile azide Ugi five-center four-component reaction (U-5C-4CR) using ketones, sodium azide, ammonium chloride, and corresponding isocyanide. The aforementioned tetrazolodiazepines represent a notable class of compounds with proven platelet aggregation inhibitory and cholecystokinin agonist activities.