Fabrication of Hollow and Porous Structured GdVO4:Dy3+ Nanospheres as Anticancer Drug Carrier and MRI Contrast Agent

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• 作者：Xiaojiao Kang ; Dongmei Yang ; Ping鈥檃n Ma ; Yunlu Dai ; Mengmeng Shang ; Dongling Geng ; Ziyong Cheng ; Jun Lin
• 刊名：Langmuir
• 出版年：2013
• 出版时间：January 29, 2013
• 年：2013
• 卷：29
• 期：4
• 页码：1286-1294
• 全文大小：531K
• 年卷期：v.29,no.4(January 29, 2013)
• ISSN：1520-5827

文摘

Hollow and porous structured GdVO₄:Dy³⁺ spheres were fabricated via a facile self-sacrificing templated method. The large cavity allows them to be used as potential hosts for therapeutic drugs, and the porous feature of the shell allows guest molecules to easily pass through the void space and surrounding environment. The samples show strong yellow-green emission of Dy³⁺ (485 nm, ⁴F_9/2 鈫?⁶H_15/2; 575 nm, ⁴F_9/2 鈫?⁶H_13/2) under UV excitation. The emission intensity of GdVO₄:Dy³⁺ was weakened after encapsulation of anticancer drug (doxorubicin hydrochloride, DOX) and gradually restored with the cumulative released time of DOX. These hollow spheres were nontoxic to HeLa cells, while DOX-loaded samples led to apparent cytotoxicity as a result of the sustained release of DOX. ICP measurement indicates that free toxic Gd ions can hardly dissolate from the matrix. The endocytosis process of DOX-loaded hollow spheres is observed using confocal laser scanning microscopy (CLSM). Furthermore, GdVO₄:Dy³⁺ hollow spheres can be used for T₁-weighted magnetic resonance (MR) imaging. These results implicate that the luminescent GdVO₄:Dy³⁺ spheres with hollow and porous structure are promising platforms for drug storage/release and MR imaging.