CuI/I2-Promoted Electrophilic Tandem Cyclization of 2-Ethynylbenzaldehydes with ortho-Benzenediamines: Synthesis of Iodoisoquinoline-Fused Benzimidazoles

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• 作者：Huang-Che Ouyang ; Ri-Yuan Tang ; Ping Zhong ; Xing-Guo Zhang ; Jin-Heng Li
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：January 7, 2011
• 年：2011
• 卷：76
• 期：1
• 页码：223-228
• 全文大小：892K
• 年卷期：v.76,no.1(January 7, 2011)
• ISSN：1520-6904

文摘

An efficient tandem route to the synthesis of iodoisoquinoline-fused benzimidazole derivatives including an iodocyclization strategy has been developed. In the presence of CuI, a variety of 2-ethynylbenzaldehydes underwent the tandem reaction with benzenediamines and iodine to afford the corresponding iodoisoquinoline-fused benzimidazoles in moderate to good yields.