Anti-inflammatory Diterpenoids from the Root Bark of Acanthopanax gracilistylus
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- 作者：Zhi-Yuan Wu ; Yi-Bei Zhang ; Kong-Kai Zhu ; Cheng Luo ; Jing-Xian Zhang ; Chun-Ru Cheng ; Rui-Hong Feng ; Wen-Zhi Yang ; Feng Zeng ; Yang Wang ; Ping-Ping Xu ; Ji-Ling Guo ; Xuan Liu ; Shu-Hong Guan ; De-An Guo
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：November 26, 2014
- 年：2014
- 卷：77
- 期：11
- 页码：2342-2351
- 全文大小：425K
- ISSN：1520-6025
文摘
Five new ent-pimarane (1鈥?b>3, 7, and 8) and three new ent-kaurane diterpenoids (4鈥?b>6) and a new oleanane triterpene acid (9), together with 22 known compounds, were isolated from the root bark of the medicinal herb Acanthopanax gracilistylus. The structures of 1鈥?b>9 were established based on the interpretation of high-resolution MS and 1D- and 2D-NMR data. The absolute configurations of 7 and 11 were determined by single-crystal X-ray diffraction and electronic circular dichroism analysis. Compounds 7 and 8 represent rare naturally occurring structures based on the devinyl ent-pimarane skeleton. Compounds 3, 10, 14, 16, and 17 exhibited potent inhibitory effects on the release of interleukin-1尾 (IL-1尾), interleukin-8 (IL-8), and tumor necrosis factor (TNF-伪) in lipopolysaccharide-stimulated peripheral blood mononuclear cells.