Trigohowilols A鈥揋, Degraded Diterpenoids from the Stems of Trigonostemon howii

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• 作者：Gui-Hua Tang ; Yu Zhang ; Chun-Mao Yuan ; Yan Li ; Yu-Cheng Gu ; Ying-Tong Di ; Yue-Hu Wang ; Guo-Ying Zuo ; Shi-Fei Li ; Shun-Lin Li ; Hong-Ping He ; Xiao-Jiang Hao
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：November 26, 2012
• 年：2012
• 卷：75
• 期：11
• 页码：1962-1966
• 全文大小：279K
• 年卷期：v.75,no.11(November 26, 2012)
• ISSN：1520-6025

文摘

Two new degraded diterpenoids, trigohowilols A (1) and B (2), four new heterodimers, trigohowilols C鈥揊 (3鈥?b>6), one new homodimer, trigohowilol G (7), and three known degraded diterpenoids (8鈥?b>10) were isolated from the methanol extract of the stems of Trigonostemon howii. Compounds 1鈥?b>7 were evaluated for their cytotoxic activity against five human tumor cell lines by an MTT assay, and trigohowilols E (5) and F (6) exhibited inhibitory activity with IC₅₀ values ranging from 2.33 to 12.57 渭M. Moreover, compounds 1鈥?b>6 showed weak antimicrobial activities (MIC values: 6.25鈥?5 渭g/mL) against Staphylococcus aureus, Pseudomonas aeruginosa, MRSA 92^#, and MRSA 98^# using a 2-fold dilution method.