Cycloaddition of Chiral tert-Butanesulfinimines with Trimethylenemethane

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• 作者：George Procopiou ; William Lewis ; Gareth Harbottle ; Robert A. Stockman
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：April 19, 2013
• 年：2013
• 卷：15
• 期：8
• 页码：2030-2033
• 全文大小：251K
• 年卷期：v.15,no.8(April 19, 2013)
• ISSN：1523-7052

文摘

The cycloaddition of chiral tert-butanesulfinimines with trimethylenemethane is found to give facile access to methylene-pyrrolidines with good yields and diastereoselectivities. The full scope of the cycloaddition is explored, and a range of transformations of the formed methylenepyrrolidines to give a range of functionalized chiral pyrrolidines is presented.