Dehydrogenative Cross-Coupling Reaction by Cooperative Transition-Metal and Br酶nsted Acid Catalysis for the Synthesis of 尾-Quinolinyl 伪-Amino Acid Esters

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• 作者：Zhi-Qiang Zhu ; Peng Bai ; Zhi-Zhen Huang
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：September 19, 2014
• 年：2014
• 卷：16
• 期：18
• 页码：4881-4883
• 全文大小：290K
• ISSN：1523-7052

文摘

A novel dehydrogenative cross-coupling (DCC) reaction between methylquinoline derivatives and N-aryl glycine esters was developed by a cooperative catalysis of copper salt and Br酶nsted acid, affording an efficient synthesis of 尾-quinolinyl 伪-amino acid esters. A plausible mechanism using a proton to activate the methylquinoline derivative and copper(II) to activate N-aryl glycine ester has been proposed.