Varitatin A, a Highly Modified Fatty Acid Amide from Penicillium variabile Cultured with a DNA Methyltransferase Inhibitor

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• 作者：Xueqian He ; Zhenzhen Zhang ; Yinghan Chen ; Qian Che ; Tianjiao Zhu ; Qianqun Gu ; Dehai Li
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：November 25, 2015
• 年：2015
• 卷：78
• 期：11
• 页码：2841-2845
• 全文大小：291K
• ISSN：1520-6025

文摘

A new, highly modified fatty acid amide, varitatin A (1), was isolated from the fungus Penicillium variabile HXQ-H-1 cultivated with the DNA methyltransferase inhibitor 5-azacytidine. The structure including the absolute configuration of 1 was established by analysis of NMR and MS data, together with chemical degradation and Mosher鈥檚 method based on MPA esters. Compound 1 showed cytotoxicity against HCT-116 cells with an IC₅₀ value of 2.8 渭M and also inhibited the effects of protein tyrosine kinases.