NMP and O2 as Radical Initiator: Trifluoromethylation of Alkenes to Tertiary 尾-Trifluoromethyl Alcohols at Room Temperature

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• 作者：Chao Liu ; Qingquan Lu ; Zhiyuan Huang ; Jian Zhang ; Fan Liao ; Pan Peng ; Aiwen Lei
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：December 18, 2015
• 年：2015
• 卷：17
• 期：24
• 页码：6034-6037
• 全文大小：365K
• ISSN：1523-7052

文摘

A novel strategy was developed to trigger 路CF₃ by using in situ generated peroxide in NMP under O₂ or air as the radical initiator. Radical trifluoromethylation of alkenes was achieved toward tertiary 尾-trifluoromethyl alcohols. Various tertiary 尾-trifluoromethyl alcohols can be synthesized in good yields without extra oxidants or transition metal catalysts. Preliminary mechanistic investigation revealed that O₂ diffusion can influence the reaction rate.