Sub-10 nm Fe3O4@Cu2鈥?i>xS Core鈥揝hell Nanoparticles for Dual-Modal Imaging and Photothermal Therapy

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• 作者：Qiwei Tian ; Junqing Hu ; Yihan Zhu ; Rujia Zou ; Zhigang Chen ; Shiping Yang ; Runwei Li ; Qianqian Su ; Yu Han ; Xiaogang Liu
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：June 12, 2013
• 年：2013
• 卷：135
• 期：23
• 页码：8571-8577
• 全文大小：544K
• 年卷期：v.135,no.23(June 12, 2013)
• ISSN：1520-5126

文摘

Photothermal nanomaterials have recently attracted significant research interest due to their potential applications in biological imaging and therapeutics. However, the development of small-sized photothermal nanomaterials with high thermal stability remains a formidable challenge. Here, we report the rational design and synthesis of ultrasmall (<10 nm) Fe₃O₄@Cu_2鈥?i>xS core鈥搒hell nanoparticles, which offer both high photothermal stability and superparamagnetic properties. Specifically, these core鈥搒hell nanoparticles have proven effective as probes for T₂-weighted magnetic resonance imaging and infrared thermal imaging because of their strong absorption at the near-infrared region centered around 960 nm. Importantly, the photothermal effect of the nanoparticles can be precisely controlled by varying the Cu content in the core鈥搒hell structure. Furthermore, we demonstrate in vitro and in vivo photothermal ablation of cancer cells using these multifunctional nanoparticles. The results should provide improved understanding of synergistic effect resulting from the integration of magnetism with photothermal phenomenon, important for developing multimode nanoparticle probes for biomedical applications.