Injectable Thermally Responsive Mucoadhesive Gel for Sustained Protein Delivery

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• 作者：Laura Mayol ; Marco Biondi ; Fabiana Quaglia ; Sabato Fusco ; Assunta Borzacchiello ; Luigi Ambrosio ; Maria I. La Rotonda
• 刊名：Biomacromolecules
• 出版年：2011
• 出版时间：January 10, 2011
• 年：2011
• 卷：12
• 期：1
• 页码：28-33
• 全文大小：253K
• 年卷期：v.12,no.1(January 10, 2011)
• ISSN：1526-4602

文摘

Poloxamer thermoresponsive gels are widely explored in controlled drug delivery. Nevertheless, these gels possess inadequate mechanical properties, poor bioadhesiveness, and high permeability to water. To overcome these issues, we blended mucoadhesive hyaluronic acid (HA) with poloxamer analogs. This study aimed to investigate the features affecting the microscopic properties of the gels, which determine their macroscopic properties and capability to control/sustain protein release. Results showed that HA hampers water鈭抪oloxamer interactions, thus, strongly influencing physicochemical properties of poloxamer gels. This leads to gels with improved mechanical properties in which the diffusion kinetics of macromolecular active molecules are drastically slowed down. Poloxamer-HA gels can sustain the delivery of proteins, such as insulin, and may allow the modulation of its release kinetics by modifying HA content within the gels in the administration sites in which the active molecule release mechanism is mainly governed by its diffusion.