Baeyer鈥揤illiger C鈥揅 Bond Cleavage Reaction in Gilvocarcin and Jadomycin Biosynthesis

详细信息    查看全文

• 作者：Nidhi Tibrewal ; Pallab Pahari ; Guojun Wang ; Madan K. Kharel ; Caleb Morris ; Theresa Downey ; Yanpeng Hou ; Tim S. Bugni ; J眉rgen Rohr
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：November 7, 2012
• 年：2012
• 卷：134
• 期：44
• 页码：18181-18184
• 全文大小：352K
• 年卷期：v.134,no.44(November 7, 2012)
• ISSN：1520-5126

文摘

GilOII has been unambiguously identified as the key enzyme performing the crucial C鈥揅 bond cleavage reaction responsible for the unique rearrangement of a benz[a]anthracene skeleton to the benzo[d]naphthopyranone backbone typical of the gilvocarcin-type natural anticancer antibiotics. Further investigations of this enzyme led to the isolation of a hydroxyoxepinone intermediate, leading to important conclusions regarding the cleavage mechanism.