Mycoleptones A–C and Polyketides from the Endophyte Mycoleptodiscus indicus
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- 作者：Willian J. Andrioli ; Raphael Conti ; Magali J. Araújo ; Riccardo Zanasi ; Bruno C. Cavalcanti ; Viviane Manfrim ; Juliano S. Toledo ; Daniele Tedesco ; Manoel O. de Moraes ; Cláudia Pessoa ; Angela K. Cruz ; Carlo Bertucci ; José Sabino ; Dhammika N. P. Nanayakkara ; M?nica. T. Pupo ; Jairo K. Bastos
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：January 24, 2014
- 年：2014
- 卷：77
- 期：1
- 页码：70-78
- 全文大小：412K
- ISSN：1520-6025
文摘
Three new azaphilones with an unusual methylene bridge, named mycoleptones A, B, and C (2, 4, and 5), were isolated from cultures of Mycoleptodiscus indicus, a fungus associated with the South American medicinal plant Borreria verticillata. Additionally, four known polyketides, austdiol (1), eugenitin (3), 6-methoxyeugenin (6), and 9-hydroxyeugenin (7), were also isolated. The structural characterization of compounds was carried out by nuclear magnetic resonance spectroscopy, high-resolution mass spectrometry, electronic circular dichroism spectroscopy, time-dependent density functional theory calculations, and X-ray crystallography. Compounds 1鈥?b>9 were weakly active when tested in antileishmanial and cytotoxicity assays.