Rapid and Sensitive Detection of Respiratory Virus Molecular Signatures Using a Silver Nanorod Array SERS Substrate

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• 作者：Saratchandra Shanmukh ; Les Jones ; Jeremy Driskell ; Yiping Zhao ; Richard Dluhy ; Ralph A. Tripp
• 刊名：Nano Letters
• 出版年：2006
• 出版时间：November 2006
• 年：2006
• 卷：6
• 期：11
• 页码：2630 - 2636
• 全文大小：240K
• 年卷期：v.6,no.11(November 2006)
• ISSN：1530-6992

文摘

A spectroscopic assay based on surface enhanced Raman scattering (SERS) using silver nanorod array substrates has been developed thatallows for rapid detection of trace levels of viruses with a high degree of sensitivity and specificity. This novel SERS assay can detect spectraldifferences between viruses, viral strains, and viruses with gene deletions in biological media. The method provides rapid diagnostics fordetection and characterization of viruses generating reproducible spectra without viral manipulation.