Type 1 Phototherapeutic Agents. 2. Cancer Cell Viability and ESR Studies of Tricyclic Diarylamines

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• 作者：Raghavan Rajagopalan ; Tien-Sung Lin ; Amolkumar S. Karwa ; Amruta R. Poreddy ; Bethel Asmelash ; Richard B. Dorshow
• 刊名：ACS Medicinal Chemistry Letters
• 出版年：2012
• 出版时间：April 12, 2012
• 年：2012
• 卷：3
• 期：4
• 页码：284-288
• 全文大小：294K
• 年卷期：v.3,no.4(April 12, 2012)
• ISSN：1948-5875

文摘

Type 1 phototherapeutic agents based on diarylamines were assessed for free radical generation and evaluated in vitro for cell death efficacy in the U937 leukemia cancer cell line. All of the compounds were found to produce copious free radicals upon photoexcitation with UV-A and/or UV鈥揃 light, as determined by electron spin resonance (ESR) spectroscopy. Among the diarylamines, the most potent compounds were acridan (<b>4b>) and 9-phenylacridan (<b>5b>), with ICb>50b> values of 0.68 渭M and 0.17 渭M, respectively.<br>

Keywords:

Diarylamines; ROS; type 1; type 2; photosensitizers; radicals; ESR