Emergence of a Single Solid Chiral State from a Nearly Racemic Amino Acid Derivative

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• 作者：Wim L. Noorduin ; Toshiko Izumi ; Alessia Millemaggi ; Michel Leeman ; Hugo Meekes ; Willem J. P. Van Enckevort ; Richard M. Kellogg ; Bernard Kaptein ; Elias Vlieg ; Donna G. Blackmond
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：January 30, 2008
• 年：2008
• 卷：130
• 期：4
• 页码：1158 - 1159
• 全文大小：53K
• 年卷期：v.130,no.4(January 30, 2008)
• ISSN：1520-5126

文摘

The evolution of a single chiral solid state is reported for an amino acid derivative starting from a nearly racemic mixture of solid left- and right-handed crystals. Attrition-enhanced dissolution and recrystallization processes based on solubility considerations of the Gibbs-Thomson rule, coupled with solution-phase racemization, drive this near-equilibrium system inexorably to single chirality in the solid phase.