Regiospecific Prenylation of Hydroxyxanthones by a Plant Flavonoid Prenyltransferase

详细信息    查看全文

• 作者：Ruishan Wang ; Ridao Chen ; Jianhua Li ; Xiao Liu ; Kebo Xie ; Dawei Chen ; Ying Peng ; Jungui Dai
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：August 26, 2016
• 年：2016
• 卷：79
• 期：8
• 页码：2143-2147
• 全文大小：307K
• 年卷期：0
• ISSN：1520-6025

文摘

C-Prenylated xanthones are pharmacologically attractive specialized metabolites that are distributed in plants and microorganisms. The prenylation of xanthones often contributes to the structural diversity and biological activities of these compounds. However, efficient regiospecific prenylation of xanthones is still challenging. In this study, the regiospecific prenylation of a number of structurally different hydroxyxanthones (3–10) by MaIDT, a plant flavonoid prenyltransferase with substrate flexibility from Morus alba, is demonstrated. Among the enzymatic products, 2-dimethylallyl-1,3,7-trihydroxyxanthone (3a) effectively attenuated glutamate-induced injury in SK-N-SH neuroblastoma cells. These results suggest a potential approach for the synthesis of bioactive prenylated xanthones by a substrate-relaxed flavonoid prenyltransferase.