Alkali Metal-Hydroxide-Catalyzed C(sp)–H Bond silylation

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• 作者：Anton A. Toutov ; Kerry N. Betz ; David P. Schuman ; Wen-Bo Liu ; Alexey FedorovBrian M. Stoltz ; Robert H. Grubbs
• 刊名：Journal of the American Chemical Society
• 出版年：2017
• 出版时间：February 1, 2017
• 年：2017
• 卷：139
• 期：4
• 页码：1668-1674
• 全文大小：693K
• ISSN：1520-5126

文摘

Disclosed is a mild, scalable, and chemoselective catalytic cross-dehydrogenative C–H bond functionalization protocol for the construction of C(sp)–Si bonds in a single step. The scope of the alkyne and hydrosilane partners is substantial, providing an entry point into various organosilane building blocks and additionally enabling the discovery of a number of novel synthetic strategies. Remarkably, the optimal catalysts are NaOH and KOH.