New Ground for Organic Catalysis: A Ring-Opening Polymerization Approach to Hydrogels
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- 作者：Fredrik Nederberg ; Vivian Trang ; Russell C. Pratt ; Andrew F. Mason ; Curtis W. Frank ; Robert M. Waymouth ; James L. Hedrick
- 刊名：Biomacromolecules
- 出版年：2007
- 出版时间：November 2007
- 年：2007
- 卷：8
- 期：11
- 页码：3294 - 3297
- 全文大小：147K
- 年卷期：v.8,no.11(November 2007)
- ISSN：1526-4602
文摘
Herein, we describe an organocatalytic living polymerization approach to network and subsequent hydrogelformation. Cyclic carbonate-functionalized macromolecules were ring-opened using an alcoholic initiator in thepresence of an organic catalyst, amidine 1,8-diazabicyclo[5.4.0]undec-7-ene. A model reaction for the cross-linking identified monomer concentration-dependent reaction regimes, and enhanced kinetic control wasdemonstrated by introducing a comonomer, trimethylene carbonate. The addition of the comonomer facilitatednear-quantitative conversion of monomer to polymer (>96%). Resulting poly(ethylene glycol) networks swellsignificantly in water, and an open co-continuous (water-gel) porous structure was observed by scanning electronmicroscopy. The organocatalytic ring-opening polymerization of cyclic carbonate functional macromonomersusing alcoholic initiators provides a simple, efficient, and versatile approach to hydrogel networks.