PEGylated Nanoparticles Obtained through Emulsion Polymerization as Paclitaxel Carriers
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- 作者：Claudio Colombo ; Lavinia Morosi ; Ezia Bello ; Raffaele Ferrari ; Simonetta Andrea Licandro ; Monica Lupi ; Paolo Ubezio ; Massimo Morbidelli ; Massimo Zucchetti ; Maurizio D’Incalci ; Davide Moscatelli ; Roberta Frapolli
- 刊名：Molecular Pharmaceutics
- 出版年：2016
- 出版时间：January 4, 2016
- 年：2016
- 卷：13
- 期：1
- 页码：40-46
- 全文大小：364K
- ISSN：1543-8392
文摘
Polymer nanoparticles (NPs) represent a promising way to deliver poorly water-soluble anticancer drugs without the use of unwanted excipients, whose presence can be the cause of severe side effects. In this work, a Cremophor-free formulation for paclitaxel (PTX) has been developed by employing PEGylated polymer nanoparticles (NPs) as drug delivery carriers based on modified poly(ε-caprolactone) macromonomers and synthesized through free radical emulsion polymerization. Paclitaxel was loaded in the NPs in a postsynthesis process which allowed to obtain a drug concentration suitable for in vivo use. In vivo experiments on drug biodistribution and therapeutic efficacy show comparable behavior between the NPs and the Cremophor formulation, also showing good tolerability of the new formulation proposed.