Dearomative Indole (3 + 2) Reactions with Azaoxyallyl Cations 鈥?New Method for the Synthesis of Pyrroloindolines

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• 作者：Maria C. DiPoto ; Russell P. Hughes ; Jimmy Wu
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：December 2, 2015
• 年：2015
• 卷：137
• 期：47
• 页码：14861-14864
• 全文大小：383K
• ISSN：1520-5126

文摘

Herein, we report the first examples of the synthesis of pyrroloindolines by means of (3 + 2) dearomative annulation reactions between 3-substituted indoles and highly reactive azaoxyallyl cations. Computational studies using density functional theory (DFT) (B3LYP-D3/6-311G**++) support a stepwise reaction pathway in which initial C鈥揅 bond formation takes place at C3 of indole, followed by ring closure to give the observed products. Insights gleaned from these calculations indicate that the solvent, either TFE or HFIP, can stabilize the transition state through H-bonding interactions with oxygen of the azaoxyallyl cation and other relevant intermediates, thereby increasing the rates of these reactions.