Regio- and Stereoselective Syntheses of the Natural Product CCR5 Antagonist Anibamine and its Three Olefin Isomers
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- 作者：Feng Zhang ; Saheem Zaidi ; Kendra M. Haney ; Glen E. Kellogg ; Yan Zhang
- 刊名：Journal of Organic Chemistry
- 出版年：2011
- 出版时间：October 7, 2011
- 年：2011
- 卷：76
- 期：19
- 页码：7945-7952
- 全文大小：897K
- 年卷期：v.76,no.19(October 7, 2011)
- ISSN：1520-6904
文摘
The syntheses of the natural product anibamine and its three olefin isomers have been achieved concisely and efficiently via highly regio- and stereoselective reactions. The crucial steps included a regioselective palladium-catalyzed alkynylation by Sonogashira coupling and a stereoselective Suzuki coupling. Further conformation analyses and in vitro calcium mobilization studies were carried out to characterize the compounds鈥?biological properties.