Self-Assembled Nanogels of Cholesterol-Bearing Hydroxypropyl Cellulose: A Thermoresponsive Building Block for Nanogel Tectonic Materials

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• 作者：Yoshiro Tahara ; Mizuki Sakiyama ; Shigeo Takeda ; Tomoki Nishimura ; Sada-atsu Mukai ; Shin-ichi Sawada ; Yoshihiro Sasaki ; Kazunari Akiyoshi
• 刊名：Langmuir
• 出版年：2016
• 出版时间：November 29, 2016
• 年：2016
• 卷：32
• 期：47
• 页码：12283-12289
• 全文大小：389K
• ISSN：1520-5827

文摘

Hydroxypropyl cellulose (HPC) is a fascinating polysaccharide to use in developing a nanogel to be a thermoresponsive building unit for nanogel tectonic materials. Cholesterol-bearing HPC (Ch-HPC) self-assembled to form nanogels through hydrophobic interactions of the cholesteryl groups in water. Ch-HPC nanogels had a lower critical solution temperature in line with that of native HPC. The particle size of Ch-HPC nanogels was reversibly controlled by the temperature and salting-out effect. The thermoresponsive property was also observed in Ch-HPC nanogel-cross-linked macrogels. These results suggest that a Ch-HPC nanogel is an attractive building block for thermoresponsive nanogel tectonic materials.