meso-Tetrakis(p-sulfonatophenyl)N-Confused Porphyrin Tetrasodium Salt: A Potential Sensitizer for Photodynamic Therapy

详细信息    查看全文

• 作者：Ajesh P. Thomas ; P. S. Saneesh Babu ; S. Asha Nair ; S. Ramakrishnan ; Danaboyina Ramaiah ; Tavarekere K. Chandrashekar ; A. Srinivasan ; M. Radhakrishna Pillai
• 刊名：Journal of Medicinal Chemistry
• 出版年：2012
• 出版时间：June 14, 2012
• 年：2012
• 卷：55
• 期：11
• 页码：5110-5120
• 全文大小：519K
• 年卷期：v.55,no.11(June 14, 2012)
• ISSN：1520-4804

文摘

A water-soluble derivative of N-confused porphyrin (NCP) was synthesized, and the photodynamic therapeutic (PDT) application was investigated by photophysical and in vitro studies. High singlet oxygen quantum yield in water at longer wavelength and promising IC₅₀ values in a panel of cancer cell lines ensure the potential candidacy of the sensitizer as a PDT drug. Reactive oxygen species (ROS) generation on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated using different techniques.