Ansalactams B–D Illustrate Further Biosynthetic Plasticity within the Ansamycin Pathway

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• 作者：Tu Cam Le ; Inho Yang ; Yeo Joon Yoon ; Sang-Jip Nam ; William Fenical
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：18
• 期：9
• 页码：2256-2259
• 全文大小：268K
• 年卷期：0
• ISSN：1523-7052

文摘

Further chemical investigation of a marine-derived bacterium of the genus Streptomyces has led to the isolation of ansalactams B–D (1–3) along with the previously reported metabolite ansalactam A (4). Ansalactams B–D are significantly modified ansamycins, representing three new carbon skeletons and further illustrating the biosynthetic plasticity of the ansalactam class. Unlike ansalactam A, ansalactams B and D are penta- and hexacyclic metabolites, while ansalactam C illustrates an open polyene chain with a terminal carboxylic acid.