Bioactive Cycloperoxides Isolated from the Puerto Rican Sponge Plakortis halichondrioides

详细信息    查看全文

• 作者：Carlos Jimnez-Romero ; Idelisse Ortiz ; Jan Vicente ; Brunilda Vera ; Abimael D. Rodrguez ; Sangkil Nam ; Richard Jove
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：October 22, 2010
• 年：2010
• 卷：73
• 期：10
• 页码：1694-1700
• 全文大小：220K
• 年卷期：v.73,no.10(October 22, 2010)
• ISSN：1520-6025

文摘

Two new five-membered-ring polyketide endoperoxides, epiplakinic acid F methyl ester (1) and epiplakinidioic acid (3), and a peroxide-lactone, plakortolide J (2), were isolated from the Puerto Rican sponge Plakortis halichondrioides, along with two previously reported cyclic peroxides, 4 and 5. The structures of the new metabolites were determined by spectroscopic and chemical analyses. The absolute stereostructures of 1, 2, and 5 were determined by degradation reactions followed by application of Kishi’s method for the assignment of absolute configuration of alcohols. Biological screening of cycloperoxides 1−5 and semisynthetic analogues 7−12 for cytotoxic activity against various human tumor cell lines revealed that compounds 3, 4, and 11 are very active. Upon assaying for antimalarial and antitubercular activity, some of the compounds tested showed strong activity against the pathogenic microbes Plasmodium falciparum and Mycobacterium tuberculosis.