Oxidative Radical Addition–Cyclization of Sulfonyl Hydrazones with Simple Olefins by Binary Acid Catalysis

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• 作者：Xingren Zhong ; Jian Lv ; Sanzhong Luo
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：July 1, 2016
• 年：2016
• 卷：18
• 期：13
• 页码：3150-3153
• 全文大小：366K
• 年卷期：0
• ISSN：1523-7052

文摘

An unprecedented binary acid accelerated oxidative radical annulation of sulfonyl hydrazones with simple olefins is described. Notably, this method provides a novel oxidative radical cycloaddition for the construction of six-member heterocycles. It offers a rapid and efficient approach to tetrahydropyridazines which are key structural motifs in pharmaceutically active compounds.