Immunoproteomic Approach to Elucidating the Pathogenesis of Cryptococcosis Caused by Cryptococcus gattii
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- 作者：Sarah E. Jobbins ; Cameron J. Hill ; Jocelyn M. D’ ; Souza-Basseal ; Matthew P. Padula ; Ben R. Herbert ; Mark B. Krockenberger
- 刊名：Journal of Proteome Research
- 出版年：2010
- 出版时间：August 6, 2010
- 年：2010
- 卷：9
- 期：8
- 页码：3832-3841
- 全文大小：326K
- 年卷期：v.9,no.8(August 6, 2010)
- ISSN：1535-3907
文摘
Cryptococcosis caused by Cryptococcus gattii is a devastating disease of immunocompetent hosts with an incompletely understood pathogenesis. Utilizing an immunoproteomic approach in a naturally occurring koala model of disease, a number of key proteins and pathways are identified in the early and late pathogenesis of cryptococcosis for the first time. In particular, the thioredoxin system appears important in the pathogenesis of cryptococcosis caused by C. gattii VGII.