Heteroarylation of Azine N-Oxides

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• 作者：Francis Gosselin ; Scott J. Savage ; Nicole Blaquiere ; Steven T. Staben
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：February 3, 2012
• 年：2012
• 卷：14
• 期：3
• 页码：862-865
• 全文大小：748K
• 年卷期：v.14,no.3(February 3, 2012)
• ISSN：1523-7052

文摘

Azine N-oxides undergo highly regioselective metalation with TMPZnCl路LiCl under mild conditions. A palladium-catalyzed Negishi cross-coupling reaction of the resulting organozinc species with heteroaromatic bromides provides heterobiaryls specifically oxidized at one nitrogen position in up to 95% yield.