Co
mplexing catalytic a
mounts of CuH with a nonrace
mic JOSIPHOS or SEGPHOS ligand, together with stoichio
metric PMHS, leads to exceedingly efficient and highly enantioselective 1,4-reductions of
mages/gifchars/beta2.gif" BORDER=0 ALIGN="
middle">,
mages/gifchars/beta2.gif" BORDER=0 ALIGN="
middle">-disubstituted enoates and lactones. An unprecedented substrate-to-ligand ratio of 7700:1 for this type of reaction is docu
mented.