Poly(ethylene glycol) Corona Chain Length Controls End-Group-Dependent Cell Interactions of Dendron Micelles

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• 作者：Hao-jui Hsu ; Soumyo Sen ; Ryan M. Pearson ; Sayam Uddin ; Petr Kr谩l ; Seungpyo Hong
• 刊名：Macromolecules
• 出版年：2014
• 出版时间：October 14, 2014
• 年：2014
• 卷：47
• 期：19
• 页码：6911-6918
• 全文大小：410K
• ISSN：1520-5835

文摘

To systematically investigate the relationship among surface charge, PEG chain length, and nano鈥揵io interactions of dendron-based micelles (DMs), a series of PEGylated DMs with various end groups (鈭扤H₂, 鈭扐c, and 鈭扖OOH) and PEG chain lengths (600 and 2000 g/mol) are prepared and tested in vitro. The DMs with longer PEG chains (DM_2K) do not interact with cells despite their positively charged surfaces. In sharp contrast, the DMs with shorter PEG chains (DM₆₀₀) exhibit charge-dependent cellular interactions, as observed in both in vitro and molecular dynamics (MD) simulation results. Furthermore, all DMs with different charges display enhanced stability for hydrophobic dye encapsulation compared to conventional linear-block copolymer-based micelles, by allowing only a minimal leakage of the dye in vitro. Our results demonstrate the critical roles of the PEG chain length and polymeric architecture on the terminal charge effect and the stability of micelles, which provides an important design cue for polymeric micelles.