2,3-Disubstituted Indoles via Palladium-Catalyzed Reaction of 2-Alkynyltrifluoroacetanilides with Arenediazonium Tetrafluoroborates
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- 作者：Sandro Cacchi ; Giancarlo Fabrizi ; Antonella Goggiamani ; Alcide Perboni ; Alessio Sferrazza ; Paolo Stabile
- 刊名：Organic Letters
- 出版年：2010
- 出版时间：July 16, 2010
- 年：2010
- 卷：12
- 期：14
- 页码：3279-3281
- 全文大小：169K
- 年卷期：v.12,no.14(July 16, 2010)
- ISSN：1523-7052
文摘
A novel palladium-catalyzed synthesis of free N−H 2,3-disubstituted indoles from arenediazonium tetrafluoroborates and 2-alkynyltrifluoroacetanilides is presented. The reaction tolerates a variety of useful substituents both in the starting alkyne and the arenediazonium salt, including bromo and chloro substituents, nitro, cyano, keto, ester, and ether groups, as well as ortho substituents such as methoxy and methyl groups.